Coby Comparison: Wegovy® vs. Ozempic® (Semaglutide) for Weight Loss

When it comes to weight loss medications, Wegovy® and Ozempic® are two options that often come up. Both medications are based on semaglutide, a GLP-1 agonist. Here, we’ll break down the differences and similarities between them to help you determine which might be the best fit for your health goals.

How Wegovy® and Ozempic® Work

Wegovy® and Ozempic® both contain semaglutide, a type of GLP-1 agonist. Semaglutide works by mimicking the operations of the hormone GLP-1, which is naturally produced by your body. The GLP-1 hormone plays a key role in controlling blood sugar levels and appetite. By binding to GLP-1receptors in organs such as the pancreas, stomach, and brain, semaglutide helps regulate glucose metabolism and suppresses appetite. This results in multiple physiological effects that assist with both the management of type 2 diabetes and weight loss.

Semaglutide operates in two significant ways.  

1. Insulin Release: Semaglutide triggers the pancreas to release insulin, lowering blood sugar levels, which is especially beneficial for individuals with type 2 diabetes who suffer from insufficient insulin production or insulin resistance.
2. Slows Digestion: Semaglutide also acts to slow down the rate of digestion and absorption of food in your stomach. This makes you feel full longer, which can reduce calorie intake and support weight loss.

Wegovy® and Ozempic® Dosage and Administration

Both Wegovy® and Ozempic® are administered as weekly injections using a pen device. Typically, both medications start at a low dose of 0.25 mg. The dose for Wegovy®, which is FDA-approved for weight loss, can be increased to a maximum dose of 2.4 mg per week, whereas the maximum dose for Ozempic®, which is FDA-approved for management of type 2 diabetes, is 2.0 mg per week.

Wegovy® and Ozempic® Effectiveness

Semaglutide has proven effective in aiding weight loss, particularly in non-diabetic individuals struggling with obesity. In the 2021 STEP 1 trial, participants who received 2.4 mg of semaglutide weekly, combined with a calorie-restricted diet and regular exercise, saw an average body weight reduction of 15% over 68weeks. This was significantly higher compared to the placebo group, and improvements were also noted in waist circumference, BMI, and blood pressure.

Given that both Wegovy® and Ozempic® are semaglutide-based, their effectiveness in promoting weight loss is the same.

Wegovy® and Ozempic® Side Effects

Common side effects of both medications include nausea, diarrhea, and constipation. Injection site reactions, such as redness, swelling and itching may also occur.

There are some more serious risks associated with each medication. Wegovy® may also cause serious side effects such as pancreatitis and thyroid cancer. Ozempic® may also increase the risk of diabetic retinopathy, a condition that can lead to blindness. While these potential risks are severe, the risk is generally considered to be low and should be weighed against the potential benefits of using the medications. Be sure to provide your healthcare provider with a complete medical history to help assess these risks.

Both Wegovy® and Ozempic® should be avoided if you have a history of medullary thyroid cancer or a family history of multiple endocrine neoplasia syndrome type 2 (MEN-2).

Cost and Insurance Coverage

The cost of Wegovy® and Ozempic® varies depending on factors like insurance coverage and location. As of August 2024, the average retail price for Wegovy® is around $1,400 per month, while Ozempic® is about $1,000 per month.

It's important to note that while Wegovy® is specifically approved for weight loss, Ozempic® is not, which may affect insurance coverage. If you have diabetes, you may find it easier to get coverage for Ozempic®. Always check with your insurance provider to understand what is covered and any potential out-of-pocket costs.

In addition, compounded semaglutide is available through Coby, which contain the same active ingredient as Wegovy® and Ozempic®.

Conclusion

Wegovy® and Ozempic® are essentially the same medication, with different dosing regimens. Since Wegovy® is approved for weight loss and Ozempic® is not, this may influence insurance coverage. Remember, both medications should be used in combination with a healthy diet and regular exercise for the best results. If you have any of the contra indications mentioned, be sure to discuss them with your healthcare provider.

If you are interested in learning more about GLP-1 medications or exploring if you are eligible for medication-assisted weight loss, reach out to us at Coby. Through Coby, you will work with expert providers that can guide you through the process. Find out if you’re eligible for semaglutide here and kickstart your weight loss journey today!