Article Summary
Both Wegovy® and Saxenda® belong to the GLP-1 receptor agonist class and work to reduce appetite and support weight management in similar ways. However, these weight loss medications have exhibited varying leves of efficacy. Wegovy® has shown greater weight loss efficacy, achieving an average reduction of 15% in body weight over 68 weeks compared to Saxenda®'s 6.4%.
When it comes to weight loss medications, Wegovy® and Saxenda® are two options within the same drug class, each with its own unique profile. This comparison will help you better understand these medications and assist in making an informed decision with your Coby healthcare provider.
Saxenda® (Liraglutide)
Saxenda®, approved by the FDA, is used for weight management in adults struggling with obesity. Saxenda® belongs to a class of drugs known as GLP-1 receptor agonists. It functions by enhancing insulin secretion and reducing glucagon release, which slows gastric emptying. This process helps tor educe appetite and manage cravings, thereby supporting weight loss. A study published in2015 found that participants who took a daily injection of 3.0 mg of Saxenda®, combined with diet and exercise, experienced an average weight loss of about 18 pounds after 52 weeks compared to the placebo group.
Saxenda® is administered via a daily injection, with the dose gradually increased over several weeks to a maximum of 3 mg per day. The duration of treatment varies based on individual weight loss goals.
Common side effects include nausea, vomiting, diarrhea, constipation, headache, dizziness, and abdominal discomfort. While these side effects typically decrease after a few weeks, Saxenda® can also be linked to more severe side effects, such as pancreatitis, thyroid tumors, and gall bladder disease, though these are rare.
Wegovy® (Semaglutide)
Wegovy® (semaglutide), another FDA-approved medication for weight loss, also belongs to the GLP-1 receptor agonist class. It functions similarly to Saxenda® by boosting insulin secretion and suppressing glucagon release. Research involving once-weekly Wegovy® injections over a 68-week period demonstrated significant weight loss compared to a placebo. Participants on Wegovy® saw an average reduction of 15%in body weight from their baseline.
Wegovy® is administered once a week, with the dose gradually increased over time to a maximum of 2.4 mg per week. As with Saxenda®, the length of treatment depends on the individual’s weight loss objectives.
Common side effects include gastrointestinal issues like nausea, vomiting, and diarrhea, which usually diminish after a few weeks. Wegovy®, like Saxenda®, carries a risk of serious but rare side effects, including pancreatitis, thyroid tumors, and gallbladder disease.
Comparing Wegovy® and Saxenda®
While both Wegovy® and Saxenda® are GLP-1 receptor agonists that aid in appetite suppression and weight loss, they differ in several key areas.
- Administration: Saxenda® requires daily injections, whereas Wegovy® is administered weekly, making Wegovy® a more convenient option.
- Dosage: The maximum dose of Saxenda® is 3mg per day, while for Wegovy® is 2.4 mg per week.
- Effectiveness: Both medications have proven effective for weight management. However, a 2022 randomized controlled trial (STEP-8) showed that participants on Wegovy® experienced greater weight loss (15% reduction) over 68 weeks compared to those on Saxenda® (6.4% reduction).
- Side Effects: Both Wegovy® and Saxenda® can cause gastrointestinal issues. Saxenda® may also lead to headaches, dizziness, and fatigue. According to the STEP-8 trial, side effects were slightly more prevalent among Wegovy® users compared to those on Saxenda®. Both drugs should be avoided by individuals with a history of medullary thyroid cancer, diabetic retinopathy, pancreatitis, gallstones, or hypoglycemia, and those currently on insulin therapy.
Cost and Insurance Coverage
Both medications are relatively expensive, with an average monthly cost of around $1,400. However, since both are FDA-approved for weight loss, they may be covered by insurance, particularly if you have a BMI over 27and other obesity-related conditions like hypertension or high cholesterol. Checking with your insurance provider is essential to understand potential out-of-pocket expenses.
Conclusion
While Wegovy® and Saxenda® work through similar mechanisms, differences in dosing frequency, effectiveness, and side effects may influence your choice. Wegovy® offers the convenience of weekly dosing and has shown greater efficacy in weight loss but may come with a higher incidence of side effects. Both medications cost about the same and may be covered by insurance.
How to Get Wegovy® or Saxenda®
To maximize the benefits of these medications, they should be combined with healthy lifestyle changes, including diet and exercise.
If you are interested in learning more about GLP-1 medications or exploring if you are eligible for medication-assisted weight loss, reach out to us at Coby. Through Coby, you will work with expert providers that can guide you through the process. Find out if you’re eligible here for weight loss medication and kickstart your weight loss journey today!
