When Will You Feel Side Effects from Semaglutide?

Starting GLP-1 medications can be an exciting time due to the potential benefits of weight loss and overall health improvements. However, it’s also important to be aware of potential side effects and when they’re most likely to occur during the treatment process. In this post, we'll go over some of the more significant side effects of GLP-1 medications and when they typically arise.

Quick Overview of Semaglutide and Other GLP-1 Weight Loss Medications

To start, let’s briefly review what GLP-1 medications are GLP-1, or glucagon-like peptide-1, medications are a class of drugs primarily used to treat type 2 diabetes and has also been approved for weight loss management. You might be familiar with these drugs under names like semaglutide, tirzepatide, dulaglutide, exenatide, or liraglutide. The GLP-1medications function by stimulating the pancreas to release insulin, which helps lower blood sugar. Additionally, GLP-1 medications promote feelings of fullness and reduce hunger. As with many medications that affect the body's systems, side effects can occur, particularly those related to digestion.

What Does the Research Show About Semaglutide Side Effects?

In 2021, the New England Journal of Medicine published a doubled-blind, placebo-controlled study examined the effect on overweight and obese individuals of taking a semaglutide injection of 2.4mg once weekly. The study compared these patients to those taking a placebo and assessed the type and duration of any side effects experienced. According to the findings, the most common side effects were nausea, diarrhea, vomiting, and constipation among those taking semaglutide. Diarrhea was reported as the most severe side effect, but on average, symptoms like nausea, diarrhea, and vomiting lasted only 8 days, 3 days, and 2 days respectively. Constipation was the least common but had a median duration of 35 days and was generally mild in severity.

Similarly, in the PIONEER 10 clinical trial, researchers compared patients on different doses of oral semaglutide and dulaglutide, examining side effects along with treatment efficacy. The study found that nausea and constipation were the most frequently reported side effects, occurring in a dose-dependent manner. Despite these gastrointestinal issues, only a small percentage of participants—3% to 6%—discontinued their medication due to side effects, indicating that the symptoms were often manageable and outweighed by the positive health outcomes.

Managing Semaglutide Side Effects

As highlighted in this article, most side effects with semaglutide and other GLP-1 medications arise within the first few weeks of starting treatment and tend to lessen over time. To minimize nausea, patients can begin with a lower dose and gradually increase it as their body adjusts. Eating smaller, more frequent meals is another strategy to help alleviate nausea. For issues like diarrhea or constipation, ensuring a sufficient intake of dietary fiber and staying hydrated can make a big difference. Consulting with a nutritionist may also be beneficial in managing these symptoms.

Coby's Conclusion on Semaglutide Side Effects

It is true that semaglutide and other GLP-1 medications can cause side effects, particularly early on. But remember to keep this in perspective! Semaglutide and other GLP-1 medications are generally considered safe and effective for treating type 2 diabetes and weight loss. At Coby, we work with expert providers that can prescribe these medications as part of our weight-loss program. Most patients are able to manage through any semaglutide side effects and are typically quite satisfied with their results.

If you're curious about semaglutide or otherGLP-1 medications or want to see if you're a candidate for weight loss medication assistance, contact us at Coby. Our team of experienced providers is ready to support you every step of the way. Discover your eligibility for weight loss medications and kickstart your weight loss journey with us today!